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PDK1 — RELA
Text-mined interactions from Literome
Tanaka et al., J Biol Chem 2005
:
Here we show that
PDK1 can
activate IKK/NF-kappaB signaling in addition to Akt signaling to promote cell survival ... IKKalpha is not required for
PDK1 mediated
NF-kappaB activation because NF-kappaB activation was observed in IKKalpha ( -/- ) mouse embryonic fibroblast (MEF) cells as in wild type MEF cells ... Akt, which was previously reported to activate IKKalpha, did not participate in the
PDK1 dependent IKKbeta or
NF-kappaB activation
Choi et al., Mol Cells 2005
(MAP Kinase Signaling System) :
PI3-kinase and
PDK-1 regulate HDAC1 mediated transcriptional repression of transcription factor
NF-kappaB ... Even though the crucial involvement of the PI3-kinase/Akt pathway in the anti-apoptotic activation of NF-kB is well known, the exact
role of
PDK-1 as well as PI3-kinase/Akt in
NF-kB activation is not understood ... Here we demonstrate that
PDK-1 plays a pivotal role in transcriptional activation of
NF-kB by dissociating the transcriptional co-repressor HDAC1 from the p65 subunit of NF-kB ... Etoposide activated
NF-kB through PI3-kinase/Akt, and the transcription activation domain ( TAD ) of p65 was further
activated by wild-type
PDK-1 ... Overexpression of a dominant negative
PDK-1 mutant decreased etoposide induced NF-kB transcription and further
down-regulated the ectopic HDAC1 mediated decrease in
NF-kB transcriptional activity
Parhar et al., Mol Cell Biochem 2007
:
We have investigated the
role of PKB and
PDK1 in IL-1beta induced
NF-kappaB activation ... Using a p65-S536A reporter construct, we found inhibition of only
PDK1 over-expression induced, but not PKB over-expression induced
NF-kappaB activation ... Our data reveals for the first time that
PDK1 and PKB may differentially
activate NF-kappaB , and that TPCK may subserve a useful anti-inflammatory function by inhibiting IKKbeta
Hayashi et al., Proc Natl Acad Sci U S A 2007
(Asthma...) :
Here we report that HAA
inhibits NF-kappaB activation upon T cell antigen receptor engagement by specifically targeting
PDK1
Kim et al., Mediators Inflamm 2010
:
Immunoblotting analysis suggested that CA inhibition was due to the inhibition of phosphoinositide-3-kinase (PI3K) and
phosphoinositide dependent kinase (PDK)1 as well as
nuclear factor-(NF-) kappaB activation
Chaurasia et al., Mol Cell Biol 2010
(Sepsis) :
These experiments reveal a novel
PDK-1 dependent negative feedback inhibition of TLR induced
NF-kappaB activation in macrophages in vivo