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RABEPK — TLR4

Text-mined interactions from Literome

Maldonado-Bernal et al., Parasite Immunol 2005 : The interaction of LPPG with TLR2 and TLR4 resulted in activation of NF-kappaB and release of interleukin (IL)-10, IL-12p40 , tumour necrosis factor (TNF)-alpha, and IL-8 from human monocytes
Shu et al., Clin Exp Immunol 2007 : natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-12 p40 in response to Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Brentano et al., Ann Rheum Dis 2009 (Arthritis, Rheumatoid...) : The TLR dependent induction of p19 but not p40 in RASF and the abundant expression of p19 along with the low or undetectable levels of IL23 in patients with RA provides strong evidence that p19 does not necessarily indicate the presence of IL23, as has been proposed to date
Hildebrand et al., Cell communication and signaling : CCS 2012 : This inhibition of TLR4 induced IL-12p40 expression is mediated by Gai triggered signalling as well as by Gß? dependent activation of PI3kinase and JNK.Taken together we propose the following model : LPS stimulates TLR4 mediated activation of the NF?B-pathway and thereby the production of TNF-a, IL-6 and IL-12p40
Römmler et al., J Immunol 2013 : Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7 induced TNF-a release and TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs