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PTX3 — TLR4

Text-mined interactions from Literome

Kerfoot et al., J Immunol 2004 (Encephalomyelitis, Autoimmune, Experimental) : Most importantly, we show that PTX induces intracellular signals through TLR4 , a receptor intimately associated with innate immune mechanisms
Garlanda et al., Annu Rev Immunol 2005 (Inflammation...) : PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to Toll-like receptor ( TLR ) engagement and inflammatory cytokines
Doni et al., J Leukoc Biol 2006 : Dendritic cells ( DC ) of myelomonocytic origin, but not plasmacytoid DC, are a major source of PTX3 in response to Toll-like receptor ( TLR ) engagement ... PTX3 production was induced by TLR ligands, CD40 ligand, and interleukin (IL)-1beta and was suppressed by dexamethasone, 1alpha, 25-dihydroxivitamin D3, and prostaglandin E2
Mantovani et al., Vascul Pharmacol 2006 (Cardiovascular Diseases...) : CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Zimmer et al., J Biol Chem 2008 : However, HEK293 cells transfected with murine MD-2 and human TLR4 or murine MD-2 and murine TLR4 were highly responsive to PTX ( 10 microm ), indicating that the murine MD-2/PTX interaction is required for TLR4 activation ... The species-specific difference between human and murine MD-2 activation of TLR4 by PTX can be explained by alterations of surface charge distribution ( i.e. electrostatic potential ), binding pocket size, and the locus of PTX binding within the MD-2 pocket, which results in reorganization of the 123-130 amino acid loop
Maina et al., J Leukoc Biol 2009 (Inflammation) : Divergent effects were observed with IL-10, which synergizes with TLR mediated PTX3 induction but inhibits LPS induced TSG-6 transcription
Deban et al., Biofactors 2009 (Inflammation) : PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to Toll-like receptor ( TLR ) engagement and inflammatory cytokines
Finlay et al., Glycoconj J 2010 : Tamiflu ( oseltamivir phosphate ), pertussis toxin ( PTX ) , a specific inhibitor of Gai proteins of G-protein coupled receptor ( GPCR ) and the broad range inhibitor of matrix metalloproteinase ( MMP ) galardin applied to live primary BM macrophage cells completely block TQ-induced MyD88/TLR4 complex formation
Garlanda et al., Curr Pharm Des 2011 (Atherosclerosis...) : CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Franchi et al., Brain Behav Immun 2012 : Moreover the effect on TLR4 is blocked by PTX thus indicating the involvement of a G ( i ) protein after MOR binding
Balhara et al., Frontiers in immunology 2013 : PTX3 is secreted by a diverse variety of cells, ranging from immune cells to structural cells, in response to Toll like receptor ( TLR ) engagement, inflammatory stimuli, and physical and chemical stress