Gene interactions and pathways from curated databases and text-mining

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GSK3B — PCNA

Text-mined interactions from Literome

De Moliner et al., Eur J Biochem 2003 : Three other kinases [cyclin dependent protein kinase 2 ( CDK2 ), phosphorylase kinase and glycogen synthase kinase 3beta ] exhibit approximately 10-fold weaker affinity for TBB than CK2
Chen et al., Mol Endocrinol 2005 : Inhibition of the GSK-3beta activity in P4-treated uteri by the specific inhibitor, LiCl, reversed the nuclear accumulation of cyclin D1 and in doing so, caused pRB phosphorylation and the induction of downstream genes, proliferating cell nuclear antigen and Ki67
Singh et al., International journal of biological sciences 2007 : Suppression of GSK-3beta by SB216763 ( 100 nM ) increases CREB phosphorylation, cyclin D1 and fibronectin levels
Ding et al., Neurobiol Dis 2010 (Alzheimer Disease...) : Indirubin and its derivatives have been shown to possess potent inhibitory effects on cyclin dependent protein kinase 5 and glycogen synthase kinase 3beta , two protein kinases involved in abnormal hyperphosphorylation of tau and amyloid precursor protein processing/beta-amyloid ( Abeta ) production