Gene interactions and pathways from curated databases and text-mining

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IRF1 — ISG15

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lin et al., Oncogene 2001 : vIRF-1 has been shown to downregulate the interferon- and IRF mediated transcriptional activation of ISG and murine IFNA4 gene promoters
Au et al., Nucleic Acids Res 1992 (Newcastle Disease) : However, expression of IRF-1 alone was sufficient to up-regulate the expression of two IFN stimulated genes, 2',5 ' oligoadenylate synthetase ( OAS ) and interferon stimulated ( ISG)-15 gene
Zhang et al., Biochim Biophys Acta 2006 (Carcinoma, Hepatocellular...) : Hyper activated IRF-1 and STAT1 contribute to enhanced interferon stimulated gene ( ISG ) expression by interferon alpha and gamma co-treatment in human hepatoma cells