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INS — SNAP25

Text-mined interactions from Literome

Nakamichi et al., Biochem Biophys Res Commun 1999 : To explore alpha-SNAP function in insulin exocytosis from either immature or mature secretory granules in pancreatic beta cells, we studied the effects of overexpression of adenovirus mediated wild-type alpha-SNAP and C-terminally deleted alpha-SNAP mutant ( 1-285 ) on newly synthesized proinsulin and insulin release by rat islets and MIN6 cells ... On the other hand, in MIN6 cells, alpha-SNAP overexpression scarcely affected glucose stimulated insulin release ; therefore, we examined the effect of mutant alpha-SNAP overexpression as the dominant negative inhibitor on the newly synthesized proinsulin/insulin release using the same protocol as in the rat islet experiments
Nagamatsu et al., Diabetes 1999 (Diabetes Mellitus, Type 2) : Decreased expression of t-SNARE , syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets : restoration of decreased t-SNARE proteins improves impaired insulin secretion
Gonelle-Gispert et al., J Cell Sci 2000 : The tSNARE SNAP-25 is expressed in pancreatic ( beta ) -cells and is involved in the regulated release of insulin
Huang et al., Am J Physiol Cell Physiol 2001 (Insulinoma...) : Previous reports showed that cleavage of vesicle associated membrane protein-2 ( VAMP-2 ) and synaptosomal associated protein of 25 kDa ( SNAP-25 ) by clostridial neurotoxins in permeabilized insulin secreting beta-cells inhibited Ca ( 2+ ) -evoked insulin secretion
Nevins et al., J Biol Chem 2005 : A direct interaction between Cdc42 and vesicle associated membrane protein 2 regulates SNARE dependent insulin exocytosis
Sawada et al., Endocrinol Jpn 1991 : In a functional study, C-sup significantly inhibited both basal insulin release and glucose stimulated insulin release
Sadoul et al., J Cell Biol 1995 : SNAP-25 is expressed in islets of Langerhans and is involved in insulin release ... Botulinum neurotoxins ( BoNT ) A and E were used to study the role of SNAP-25 in insulin secretion
Cunningham et al., Mol Cell Endocrinol 1994 : Insulin secretion in HIT-T15 cells was inhibited by SIN-1, SNAP and hydroxylamine and in RINm5F cells by hydroxylamine
Zhou et al., Biochem Biophys Res Commun 1997 (Insulinoma...) : These results suggest that tyrosine phosphorylation of SNAP-25 may be involved in the regulation of insulin secretion in RIN 1046-38 cells
Sadoul et al., J Biol Chem 1997 : Thus, when insulin secreting cells are permeabilized and treated with botulinum neurotoxin E ( BoNT/E ), SNAP-25 is hydrolyzed, and insulin secretion is inhibited
Huang et al., Mol Endocrinol 1998 (Insulinoma...) : Truncated SNAP-25 ( 1-197 ), like botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells ... In the present study, we show that SNAP-25 is required for insulin secretion by transient transfection of Botulinum Neurotoxin A ( BoNT/A ) into insulin secreting HIT-T15 cells