Muraoka et al., Am J Physiol Endocrinol Metab 2009
(Obesity) :
Insulin enhanced SIK2 phosphorylation at Ser ( 587 ), which was accompanied by decrease in phospho-TORC2
Küser-Abali et al., Invest Ophthalmol Vis Sci 2013
(Chronic Disease...) :
Insulin dependent changes in SIK2 activity were investigated by in vitro kinase assays in MIO-M1 Müller cell line ... The potential role of SIK2 in insulin signaling was explored by overexpression and sh-RNA knock-down approaches ... Insulin stimulation of MIO-M1 cells resulted in a rapid 2-fold increase of SIK2 activity, increased insulin receptor substrate 1 (IRS1)-SIK2 interaction, and reduced cell death