Garami et al., Mol Cell 2003
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Insulin activation of Rheb , a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 ... Here we provide evidence that TSC1/2 is a GAP for the small GTPase Rheb and that insulin mediated Rheb activation is PI3K dependent
Suryawan et al., Am J Physiol Endocrinol Metab 2007
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Furthermore, neither INS , AA, nor age had any effect on the abundance of Rheb and the phosphorylation of AMP activated protein kinase and eukaryotic elongation factor 2