Suckow et al., Endocrinology 2008
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Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion
Suckow et al., J Biol Chem 2012
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Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic ß cell function ... We previously demonstrated that ß cells express neuroligin-2 and that insulin secretion is affected by changes in neuroligin-2 expression ... Here we show that the effect of neuroligin-2 on insulin secretion is mediated by transcellular interactions ... Neuroligin-2 binds with nanomolar affinity to a partner on the ß cell surface and contributes to the increased insulin secretion brought about by ß cell-to-ß cell contact