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INS — INSIG1

Text-mined interactions from Literome

Keeton et al., Endocrinology 2005 (Carcinoma, Hepatocellular...) : In the present work, insulin 's regulation of expression of activating transcription factor 3 ( ATF-3 ), the putative transcription factor proline-rich induced protein (Pip)92, and insulin-inducible gene-1 (Insig-1) ( an ER resident protein involved in regulation of sterol-responsive element binding protein 1 activation ) have been examined in a liver derived cell line ( rat H4IIE hepatoma cells ) ... We report that : 1 ) insulin induced transcription of ATF-3, Pip92, and Insig-1 required MEK-ERK activation ; 2 ) insulin induced transcription of ATF-3 and Pip92 reached maximum levels within 15 min and was blocked by wortmannin but not LY294002 ; 3 ) in contrast, the maximum level of insulin induced transcription of Insig-1 was delayed and was not blocked by either wortmannin or LY294002 ; 4 ) insulin activated ERK1/2 in two distinct phases, a rapid peak and a later plateau ; 5 ) the delayed plateau phase of insulin induced ERK1/2 activation was partially phosphatidylinositol 3-OH-kinase dependent ; and 6 ) however, the rapid, insulin induced peak of ERK1/2 activation was blocked by wortmannin but not LY294002
Chen et al., J Biomed Sci 2011 : In addition, Insig-1 up-regulated the expression of IRS-2, PDX-1, GLUT-2 and Insulin , down-regulated the expression of UCP-2 and improved glucose stimulated insulin secretion ( GSIS ) ... In addition, Insig-1 up-regulated the expression of IRS-2, PDX-1, GLUT-2 and Insulin , down-regulated the expression of UCP-2 and improved glucose stimulated insulin secretion ( GSIS )
Boden et al., Obesity (Silver Spring) 2013 : Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue