Gene interactions and pathways from curated databases and text-mining

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IL10 — NGF

Text-mined interactions from Literome

Bulló et al., Am J Physiol Endocrinol Metab 2005 : Although interleukin (IL)-1beta, IL-10 , and IL-18 each induced a small decrease in NGF mRNA level in 3T3-L1 adipocytes, there was no significant effect of these cytokines on NGF secretion
Jelaso et al., Int J Dev Neurosci 2005 : In the mammalian nervous system, the cytokine, interleukin-1beta (IL-1beta) induces expression of NGF
Micera et al., Molecular vision 2009 (Conjunctivitis, Allergic) : NGF triggered a dose-response release of IL-10 in VKC-ECs conditioned media, an effect not detected for IL-4, IL-12 p40, and IFN-gamma
Marianecci et al., J Control Release 2010 : The treatment of HLF cells with BDP loaded non-ionic surfactant vesicles determined a noticeable increase of the drug anti-inflammatory activity by reducing the secretion of both constitutive and interleukin-1ß stimulated nerve growth factor ( as inflammatory index ) of 68 % and 85 %, respectively
Varilek et al., Am J Physiol 1995 : Caco-2 monolayers primarily secreted NGF from the basolateral compartment, and interleukin-1 enhanced its secretion
Pshenichkin et al., J Neurochem 1994 : Transcriptional and posttranscriptional mechanisms involved in the interleukin-1 , steroid, and protein kinase C regulation of nerve growth factor in cortical astrocytes
Brodie et al., FEBS Lett 1996 : We have examined the effect of the Th2 derived cytokine IL-10 and the Th1 derived cytokines Il-2 and IFN-gamma on the secretion of NGF by mouse astrocytes ... IL-10 induced a dose dependent increase in NGF secretion which was blocked by anti-IL-10 antibody ... Moreover, INF-gamma completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNF-alpha