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IKBKB — NOS2
Text-mined interactions from Literome
Schwabe et al., Hepatology 2001
:
Furthermore,
Ad5IKK2dn completely
blocked the induction of
inducible nitric oxide synthase (iNOS) , whereas Ad5IKK1dn had no influence on the expression of iNOS
Chen et al., Carcinogenesis 2005
:
Furthermore, impairing nuclear factor-kappaB (NFkappaB) activation by either NEMO-BDBP, an NFkappaB specific inhibitor, or overexpression of DN-IkappaBalpha or
IKK-KM markedly
inhibited the expression of B [ a ] P-induced
iNOS , suggesting that the NFkappaB pathway is also required for the induction of iNOS by B [ a ] P
Gomez et al., Br J Pharmacol 2005
:
These data suggest that
IKKbeta plays a predominant, selective role in the regulation of NF-kappaB dependent induction of
iNOS in RASMCs
Pan et al., Biochem Pharmacol 2006
(Cocarcinogenesis...) :
Taken together, these results show that acacetin down
regulates inflammatory
iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation
PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Pan et al., J Agric Food Chem 2008
:
Taken together, these results show that pterostilbene down
regulates inflammatory
iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of
PI3K/Akt/IKK and MAPK
Kumar et al., Carcinogenesis 2012
(Carcinoma, Squamous Cell...) :
Single application of NX ( 1.0mg/mouse ) prior to 12-O-tetradecanoylphorbol 13-acetate ( TPA ) application significantly inhibited TPA induced skin edema, hyperplasia, thymidine incorporation and ornithine decarboxylase (ODC) activity ; expression of cyclooxygenase-2 (COX-2) and
inducible nitric oxide synthase (iNOS) ; phosphorylation of extracellular signal regulated kinases ( ERK ) 1/2, p38 and c-jun N-terminal kinase ( JNK ) mitogen activated protein kinases ( MAPKs ) ; and
activation of
I kappa B kinase (IKK) , I?Ba and nuclear factor-kappa B ( NF-?B ) in mouse skin