Gene interactions and pathways from curated databases and text-mining

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IKBKB — NOS2

Text-mined interactions from Literome

Schwabe et al., Hepatology 2001 : Furthermore, Ad5IKK2dn completely blocked the induction of inducible nitric oxide synthase (iNOS) , whereas Ad5IKK1dn had no influence on the expression of iNOS
Chen et al., Carcinogenesis 2005 : Furthermore, impairing nuclear factor-kappaB (NFkappaB) activation by either NEMO-BDBP, an NFkappaB specific inhibitor, or overexpression of DN-IkappaBalpha or IKK-KM markedly inhibited the expression of B [ a ] P-induced iNOS , suggesting that the NFkappaB pathway is also required for the induction of iNOS by B [ a ] P
Gomez et al., Br J Pharmacol 2005 : These data suggest that IKKbeta plays a predominant, selective role in the regulation of NF-kappaB dependent induction of iNOS in RASMCs
Pan et al., Biochem Pharmacol 2006 (Cocarcinogenesis...) : Taken together, these results show that acacetin down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Pan et al., J Agric Food Chem 2008 : Taken together, these results show that pterostilbene down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK
Kumar et al., Carcinogenesis 2012 (Carcinoma, Squamous Cell...) : Single application of NX ( 1.0mg/mouse ) prior to 12-O-tetradecanoylphorbol 13-acetate ( TPA ) application significantly inhibited TPA induced skin edema, hyperplasia, thymidine incorporation and ornithine decarboxylase (ODC) activity ; expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) ; phosphorylation of extracellular signal regulated kinases ( ERK ) 1/2, p38 and c-jun N-terminal kinase ( JNK ) mitogen activated protein kinases ( MAPKs ) ; and activation of I kappa B kinase (IKK) , I?Ba and nuclear factor-kappa B ( NF-?B ) in mouse skin