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FUT1 — THPO

Text-mined interactions from Literome

Semerad et al., Proc Natl Acad Sci U S A 2009 : E2A-deficient HSCs also failed to efficiently maintain the HSC pool on serial transplantation, and we demonstrate that the E2A proteins regulate cell cycle progression of HSCs by regulating the expression of p21 ( Cip1 ), p27 ( Kip1 ), and the thrombopoietin receptor, known regulators of HSC self-renewal activity
Arai et al., Ann N Y Acad Sci 2009 : In contrast, administration of an anti-Mpl neutralizing antibody, AMM2, suppressed the quiescence of LT-HSCs and enabled HSC engraftment without irradiation, indicating that inhibition of THPO/Mpl signaling reduces HSC-niche interactions