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CTGF — IL6
Text-mined interactions from Literome
Karger et al., Cell Signal 2008
:
CTGF stimulated binding of NF-kappaB to the
IL-6 promoter, and siRNA targeting the NF-kappaB subunit RelA interfered with CTGF induced IL-6 expression, implicating the NF-kappaB pathway in the mediation of the CTGF effect
Gressner et al., World J Gastroenterol 2011
(Fibrosis...) :
To investigate the mechanisms involved in a possible modulator
role of
interleukin (IL)-6 signalling on CYR61-CTGF-NOV (CCN)
2/connective tissue growth factor (CTGF) expression in hepatocytes ( PC ) and to look for a relation between serum concentrations of these two parameters in patients with acute inflammation ... However, the STAT3 SH2 domain binding peptide, a selective inhibitor of STAT3 DNA binding activity, counteracted the inhibitory
effect of
IL-6 on
CCN2/CTGF expression much more pronounced than pyrrolidine-dithiocarbamate, an inhibitor primarily of STAT3 phosphorylation
Liu et al., PloS one 2012
(MAP Kinase Signaling System) :
OASFs showed significant expression of CTGF, and expression was higher than in normal SFs. OASFs stimulation with
CTGF induced concentration dependent increases in
IL-6 expression ... Our results suggest that
CTGF increased
IL-6 production in OASFs via the avß5 integrin, ASK1, p38/JNK, and AP-1/NF-?B signaling pathways
Wang et al., Mol Med Report 2013
:
CTGF stimulation
resulted in the significant production of
IL-6 , IL-8, C-C motif ligand 2 (CCL2), CCL20, MMP-1 and MMP-3 in FLSs in the presence, but not in the absence, of IL-1ß