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CASP6 — EIF4G1
Pathways - manually collected, often from reviews:
-
BioCarta internal ribosome entry pathway:
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
(modification, activates)
-
BioCarta internal ribosome entry pathway:
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
(modification, activates)
-
BioCarta internal ribosome entry pathway:
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, activates)
Text-mined interactions from Literome
Morley et al., FEBS Lett 2001
:
Furthermore, MG132 also promotes the cleavage of
eIF4G and the
activation of
caspase-3-like activity in a caspase-8-deficient Jurkat cell line which is resistant to anti-Fas mediated apoptosis
Marissen et al., Mol Cell Biol 1998
:
In addition, purified
caspase 3
caused cleavage of purified
eIF4G , demonstrating that eIF4G could serve as a substrate for caspase 3