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BCL10 — NGF

Text-mined interactions from Literome

Bui et al., J Cell Biol 2001 : Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha ... We investigated the effect of NGF on the expression of Bcl-xL , an anti-apoptotic Bcl-2 family protein ... NGF induced NFkappaB activity and Bcl-xL expression were inhibited in cells overexpressing the NFkappaB inhibitor, IkappaBalpha ... We conclude that NGF and TNF-alpha induce different signaling pathways in neurons to activate NFkappaB and bcl-x gene expression
Bui et al., J Neurochem 2002 (Pheochromocytoma) : We have previously shown that nerve growth factor (NGF) induced activation of nuclear factor-kappaB increased neuronal expression of Bcl-xL , an anti-apoptotic Bcl-2 family protein ... Treatment of hippocampal neurones with the blocking anti-p75 antibody inhibited constitutive and NGF induced Bcl-xL expression, activation of Akt, and blocked the protective effect of NGF against excitotoxic and apoptotic injury
Lindenboim et al., Exp Cell Res 2004 : Bcl-x ( S ) induces an NGF-inhibitable cytochrome c release ... These findings show that cytochrome c release and caspase-3 activation participate in Bcl-x ( S ) -induced apoptosis, and that NGF inhibits Bcl-x ( S ) -induced apoptosis at the mitochondrial level via the PKC, PI 3-kinase, and MEK signaling pathways