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BCL10 — CD28

Text-mined interactions from Literome

Dahl et al., J Exp Med 2000 : It is known that CD28 mediated signaling results in the upregulation of the Bcl family member Bcl-X ( L )
Khoshnan et al., J Immunol 2000 : Taken together, these data demonstrate that CD3/CD28 induced activation of IKK beta and expression of Bcl-xL promote the survival of primary human CD4+ T lymphocytes
Kosmaczewska et al., Arch Immunol Ther Exp (Warsz) 2001 : The interaction between the costimulatory molecule CD28 on T cells and members of the B7 family on antigen presenting cell results in upregulation of T cell proliferation and cytokine production and induces the expression of the anti-apoptotic protein Bcl-xl
Scharschmidt et al., Mol Cell Biol 2004 : Here we show that PKC or T-cell receptor ( TCR ) /CD28 signaling results in downregulation of Bcl10 protein levels, thereby attenuating NF-kappa B transcriptional activity
Tamma et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : In the present study, we showed that stimulation of normal CD4+ T cells with jacalin plus CD28 cross linking ( CD28XL ) resulted in phosphorylation of signal transducer and activator of transcription ( STAT ) -6 and expression of Bcl-2 and Bcl-xL , which were inhibited significantly when cells were cultured in the presence of the p38 mitogen activated protein kinase ( MAPK ) inhibitor SB203580
Boise et al., Curr Opin Immunol 1995 : CD28 not only enhances IL-2 production, which can act as an extrinsic regulator of cell survival, but also augments the expression of the intrinsic survival factor Bcl-xL
Mueller et al., J Immunol 1996 : Differential regulation of bcl-2 and bcl-x by CD3, CD28 , and the IL-2 receptor in cloned CD4+ helper T cells
Lin et al., J Immunol 1997 : Furthermore, CD28 costimulation can prevent anti-TNFR2 induced apoptosis and restore Bcl-xL expression
Collette et al., Blood 1998 : Conversely, CD28 mediated signals increase expression of Bcl-XL , a survival gene, and promote survival of naive T cells cultured in the absence of antigen or costimulation
Koskela et al., Scand J Immunol 1998 : In addition, we also showed that CD28 can give a costimulatory signal to gammadelta T cells and that this signal leads to up-regulation of IL-2 and bcl-x transcripts