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AKT3 — GAS6

Text-mined interactions from Literome

Goruppi et al., Mol Cell Biol 2001 : We also demonstrate that Gas6 activates Akt and concomitantly inhibits GSK3 activity in a wortmannin dependent manner
Lee et al., Oncogene 2002 (Ovarian Neoplasms) : Akt is required for Axl-Gas6 signaling to protect cells from E1A mediated apoptosis ... Thus, we conclude that activated Akt is required for Axl-Gas6 signaling to prevent E1A mediated apoptosis induced by serum deprivation
Angelillo-Scherrer et al., J Clin Invest 2005 (Thrombosis) : Gas6 , through its receptors, activates PI3K and Akt and stimulates tyrosine phosphorylation of the beta3 integrin, thereby amplifying outside-in signaling via alphaIIbbeta3
Motomura et al., Biochem Biophys Res Commun 2007 : Gas6 signaling activated the phosphorylation of ERK1/2, SAPK/JNK, and Akt , but not p38 MAPK
Llacuna et al., Hepatology 2010 (Liver Diseases...) : In line with the in vivo data, in vitro studies indicated that GAS6 induced AKT phosphorylation in primary mouse hepatocytes and thus protected them from hypoxia induced cell death, whereas GAS6 diminished lipopolysaccharide induced cytokine expression ( IL-1ß and TNF ) in murine macrophages
Kim et al., J Cell Mol Med 2012 (Kidney Diseases...) : Moreover, ALA inhibited Pi-induced down-regulation of cell survival signals through the binding of growth arrest-specific gene 6 (Gas6) to its cognate receptor Axl and subsequent Akt activation , resulting in increased survival and decreased apoptosis
Demarest et al., Biochemistry 2013 (Melanoma) : In melanoma cell lines, Gas6 induced Tyro3 phosphorylation and downstream Akt phosphorylation without apparent effects on Erk