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TFRC — TP53
Text-mined interactions from Literome
Perry et al., J Biol Chem 2000
:
p90 ( MDM2 )
inhibits p53 by blocking the transcriptional activation domain of p53 as well as by stimulating its degradation
Mendrysa et al., Mol Cell Biol 2003
(Body Weight) :
Here we provide the first conclusive demonstration that
p90MDM2 constitutively
regulates p53 activity in homeostatic tissues ... Cre mediated deletion of mdm2 caused a greater accumulation of p53, demonstrating that
p90MDM2 constitutively
regulates both the activity and the level of
p53 in homeostatic tissues
Friedman et al., Translational oncology 2013
:
Prodrug
SNX5422 similarly down modulated key signal targets,
enhanced TP53 expression and apoptosis, and inhibited proliferation, angiogenesis, and tumorigenesis in a wtTP53-deficient HNSCC xenograft model