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EZH2 — TP53

Text-mined interactions from Literome

Tang et al., Oncogene 2004 : Activated p53 suppressed EZH2 gene expression through repression of the EZH2 gene promoter ... We suggest that the p53 dependent suppression of EZH2 expression is a novel pathway that contributes to p53 mediated G2/M arrest
Cheng et al., Clin Cancer Res 2012 (Stomach Neoplasms) : In primary human gastric cancers, EZH2 expression was negatively correlated with p53 pathway activation, suggesting that higher levels of EZH2 may repress p53 activity
Seward et al., Cancer Lett 2013 (Neoplasm Invasiveness...) : EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21 ( waf1/cip1 ) and by inhibiting mutant p53 ... Further, silencing of EZH2 resulted in re-expression of p21 ( waf1/cip1 ) and down-regulation of mutant p53
Mahamodhossen et al., Med Oncol 2013 : Some of these markers are p53 induced miR-205, leptin receptor antagonist peptide, enhancer of zeste homolog 2 and Notch 1 pathway components, each of them could offer different mechanism for target therapy in TNBC