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PLCG1 — PLD2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PLCG1 — PLD2 Lee et al., J Biol Chem 2004*
• IRef Bind_translation Interaction: PLCG1 — PLD2 (affinity chromatography technology) Lee et al., J Biol Chem 2004*
• IRef Biogrid Interaction: PLCG1 — PLD2 (physical association, affinity chromatography technology) Jang et al., J Biol Chem 2003*
• IRef Biogrid Interaction: PLCG1 — PLD2 (direct interaction, pull down) Jang et al., J Biol Chem 2003*
• IRef Hprd Interaction: PLCG1 — PLD2 (in vivo) Jang et al., J Biol Chem 2003*
• IRef Hprd Interaction: PLCG1 — PLD2 (in vitro) Jang et al., J Biol Chem 2003*
• IRef Ophid Interaction: PLCG1 — PLD2 (aggregation, confirmational text mining) Jang et al., J Biol Chem 2003*
• IRef Ophid Interaction: PLCG1 — PLD2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Slaaby et al., Biochem J 2000 : Insulin induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade ... Insulin induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade
Jang et al., J Biol Chem 2003 : However, neither PLD2 wild type nor PLD2 mutant affects the EGF induced tyrosine phosphorylation of PLC-gamma1
Lee et al., J Biol Chem 1994 : Activation of phospholipase D induced by platelet derived growth factor is dependent upon the level of phospholipase C-gamma 1 ... PDGF stimulated PLD activation was 10-fold greater in 3T3-gamma 1 cells than in 3T3-C cells, indicating that PLD activation is dependent upon the level of PLC-gamma 1 ... Therefore, these results suggest that PDGF induced PLD activation may be a consequence of primary stimulation of PLC-gamma 1 and that PLD may play a role downstream from PLC-gamma 1 in PDGF triggered mitogenesis
Yeo et al., J Biol Chem 1994 : Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet derived growth factor ... In summary, these results indicate that activation of PLC gamma 1 and protein kinase C are necessary for the stimulation of PLD by PDGF and provide no evidence for alternative mechanisms