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AKT3 — PLD2
Text-mined interactions from Literome
Wang et al., Biochem Pharmacol 2003
:
Collectively, these results indicate that the inhibition by CCY1a of fMLP induced O2 ( .- ) generation in rat neutrophils can probably be attributed to the increase in cAMP levels, and to the blockade of Ca2+ entry, suppression of
Akt , and
PLD activation via cAMP independent mechanisms
Kam et al., FASEB J 2004
:
PDGF induced marked phosphorylation of
Akt ( a PI3K target ) but this was not
affected by
PLD deficiency ... LPA caused much less phosphorylation of
Akt and this was
dependent on
PLD activity
Li et al., J Pharmacol Exp Ther 2005
:
Diacylglycerol kinase inhibitor II diminished Ang II-induced and diC8-phosphatidic acid ( PA ) -increased Akt phosphorylation, suggesting that
PLD dependent
Akt activation is mediated by PA ... These data indicate that Ang II-stimulated
Akt activity is mediated by cPLA(2) dependent, p38 MAPK
regulated PLD(2) activation and EGFR transactivation
Banno et al., J Biol Chem 2005
:
Furthermore, the
PI3K/Akt activation in response to H ( 2 ) O ( 2 ) was
reduced by transfection of either
PLD2KR or the dominant negative Pyk2DN
Li et al., Am J Physiol Heart Circ Physiol 2005
(Carotid Artery Injuries) :
ANG II-induced neointimal growth is mediated via cPLA2- and
PLD2 activated
Akt in balloon injured rat carotid artery ... This study was conducted to determine whether ANG II-induced neointimal thickening is mediated via cPLA2- and
PLD2 activated
Akt in balloon injured rat carotid arteries
Kim et al., Cancer Res 2006
:
Etoposide induced activation of
Akt was
potentiated by overexpression of
PLD and PLD stimulated suppression of Egr-1 was blocked by inhibition of phosphatidylinositol 3-kinase/Akt survival pathway at the both transcriptional and posttranscriptional levels
Di Fulvio et al., Cell Signal 2008
:
Transient expression of
PLD2 in COS7 cells with either the WT or with a Y179F mutant,
resulted in an increased basal phosphorylation of
AKT in residues T308 and S473, in a PI3K dependent manner
Toschi et al., Mol Cell Biol 2009
:
Suppression of
PLD also
blocked insulin stimulated
Akt phosphorylation at Ser473 and the mTORC2 dependent phosphorylation of PRAS40