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FOXO3 — MYLIP

Text-mined interactions from Literome

Wang et al., J Biol Chem 2010 : Foxo3a regulates apoptosis by negatively targeting miR-21 ... Knockdown of Foxo3a resulted in an elevation in miR-21 levels, whereas enforced expression of Foxo3a led to a decrease in miR-21 expression ... In exploring the molecular mechanism by which Foxo3a regulates miR-21 , we observed that Foxo3a bound to the promoter region of miR-21 and suppressed its promoter activity ... These results indicate that Foxo3a can transcriptionally repress miR-21 expression ... Our data suggest that Foxo3a negatively regulates miR-21 in initiating apoptosis
Zhuo et al., J Biol Chem 2010 : These results indicated that VDUP1 expression was regulated by FOXO3A at the transcriptional level and by miR-17-5p at the post-transcriptional levels during the senescence process
Yamamoto et al., PloS one 2011 : Further studies by gain- and loss-of-function experiments supported a role for miR-155 in the regulation of FOXO3a protein expression in conventional T and HOZOT cells
Kress et al., Mol Cell 2011 (Colorectal Neoplasms) : MK5 activates miR-34b/c expression via phosphorylation of FoxO3a, thereby promoting nuclear localization of FoxO3a and enabling it to induce miR-34b/c expression and arrest proliferation
Wang et al., J Biol Chem 2012 (Cardiomegaly) : To identify the downstream targets of miR-23a, we found that transcription factor Foxo3a is suppressed by miR-23a
Yang et al., Leukemia & lymphoma 2012 (Leukemia, Lymphoid) : Furthermore, increased expression of miR-182 reduced total FOXO3A expression but had no significant effect on phospho-FOXO3A
Saxena et al., Antioxid Redox Signal 2013 (Colonic Neoplasms...) : Our results obtained with HT29 cells ablated with FOXO3a siRNA showed increased activator protein-1 (AP-1) activation and miR-21 expression, indicating that FOXO3a represses miR-21 via AP-1 inactivation
Adlakha et al., Cell death & disease 2013 : miR-128 decreased phospho-Akt and phospho-FOXO3A, increased acetylated FOXO3A and promoted FOXO3A translocation to the nucleus
Zhou et al., Circ Res 2013 (Neointima) : Endothelial miR-126 represses forkhead box O3 , B-cell lymphoma 2, and insulin receptor substrate 1 mRNAs in the cocultured SMCs, suggesting the functional roles of the transmitted miR-126
Wang et al., Cell death & disease 2013 : In exploring the molecular mechanism by which miR-874 expression is regulated, we identified that Foxo3a could transcriptionally repress miR-874 expression