◀ Back to KRAS
APC — KRAS
Text-mined interactions from Literome
Babbar et al., Biochem Soc Trans 2003
(Intestinal Neoplasms) :
Inactivation of the
APC tumour-suppressor gene, and the
activation of
K-ras , have a combined effect on increasing tissue polyamine contents due to increased synthesis and decreased catabolism of the polyamines
Phelps et al., Cell 2009
(Adenoma...) :
APC mutation
induced intestinal differentiation defects instead depend on the transcriptional corepressor C-terminal binding protein-1 (CtBP1), whereas proliferation defects and nuclear accumulation of beta-catenin require the additional activation of
KRAS
Sevignani et al., J Clin Invest 1998
(Cell Transformation, Neoplastic...) :
Distinct genetic abnormalities ( loss-of-function mutations of
APC and p53 and oncogenic
activation of
Ki-ras ) are associated with specific stages of the sporadic, most common types of colorectal tumors