Noble et al., Eur J Immunol 2001
:
However Tc1 CD8 effector development is independent of IL-12, and Tc2 cell generation requires both appropriate TCR signals and IL-4 early in effector development
Sasaki et al., Eur J Immunol 2008
(Melanoma, Experimental) :
We and others have previously demonstrated that IL-4 dependent Tc2 are inferior to Tc1-effector CD8+ T cells in regulating tumor progression in vivo