Gene interactions and pathways from curated databases and text-mining

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IL4 — IRF2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Paludan et al., Scand J Immunol 1999 (Herpes Simplex) : Furthermore, IL-4 substantially augmented the IFN-gamma induced expression of IRF-2 , which is known to compete with IRF-1 for the DNA recognition site, ISRE ( interferon stimulated response element )
Li-Weber et al., J Immunol 1994 : The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression ... Mutations of the ISRE site increased overall IL-4 promoter activity twofold, suggesting a possible negative role of IRF-2 in the regulation of IL-4 transcription