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IL13 — IL21

Text-mined interactions from Literome

Melk et al., Transplantation 2004 (Growth Disorders...) : During rhGH therapy in children with transplants, interleukin (IL)-2 production increased threefold at 4 weeks, and IL-4 and IL-13 increased by 70 % at 12 weeks
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Newcomb et al., J Immunol 2009 : Collectively, we have shown that Th17 cells express a functional IL-13R and that IL-13 negatively regulates IL-17A and IL-21 production by decreasing retinoic acid-related-gammaT expression and while increasing phosphorylation of STAT6 and GATA3 expression
Nakayamada et al., Immunity 2011 : Herein, we showed interleukin-12 acting via the transcription factor STAT4 induced both Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells
Newcomb et al., J Immunol 2012 (Pneumonia...) : We have shown previously that IL-13 inhibits Th17 cell production of IL-17A and IL-21 in vitro ... In this study, we extend our in vitro findings and determine that IL-13 increases IL-10 production from Th17 polarized cells and that IL-13 induced IL-10 production negatively regulates the secretion of IL-17A and IL-21