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CDKN1A — IL13

Text-mined interactions from Literome

Muroya et al., Oncogene 1992 : In contrast, basic fibroblast growth factor, interleukin 6 and dibutyryl cAMP, which induce neuronal differentiation of PC12 cells, did not stimulate the accumulation of p21-GTP at any time point examined
Dubourdeau et al., Eur Cytokine Netw 2008 : Opposite roles of STAT and PPARgamma in the induction of p21WAF1 expression by IL-13 in human peripheral blood monocytes ... We report here, that IL-13 increases p21WAF1 expression in human blood monocytes ... We show that the signalling pathway for IL-13 induced p21WAF1 expression may involve the IL-4R alpha and the IL-13R alpha1 chains, and the tyrosine and JAK2 kinases ... We found that inhibition of PPARgamma increases IL-13 induced p21WAF1 gene expression in these models ... These data argue that IL-13 upregulates p21WAF1 expression in monocytes via JAK/STAT pathway, and that the activation of PPARgamma by this cytokine can counteract this induction