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IFNG — TGFB2

Text-mined interactions from Literome

Qadir et al., Am J Physiol Gastrointest Liver Physiol 2001 (Granuloma, Foreign-Body...) : Interleukin-10 (IL-10) and transforming growth factor-beta ( TGF-beta ) regulate CD4+ T cell interferon-gamma (IFN-gamma) secretion in schistosome granulomas
Wen et al., Am J Respir Cell Mol Biol 2002 : Interleukin-4- and interleukin-13 enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma ... IFN-gamma reduced both basal, IL-4-, and IL-13 stimulated release of TGF-beta2 in human bronchial epithelial cells ... The stimulatory effects of IL-4 and IL-13 and the inhibitory effect of IFN-gamma on TGF-beta2 release were paralleled by mRNA levels, as assessed by real-time reverse transcriptase-polymerase chain reaction ( RT-PCR ) ... IFN-gamma , in contrast, can inhibit TGF-beta2 release both under basal conditions and following IL-4 or IL-13 stimulation
Riemekasten et al., Arthritis Rheum 2003 : Interferon-gamma (IFNgamma), interleukin-2 (IL-2), IL-4, transforming growth factor beta , and IL-10 production increased in response to the peptide in young mice ; only IFNgamma and IL-2 were increased in older, diseased mice
Kuga et al., Oncogene 2003 (Neoplasm Invasiveness...) : Interferon-gamma suppresses transforming growth factor-beta induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model
Wen et al., Am J Respir Cell Mol Biol 2004 : Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads ... Because interferon (IFN)-gamma may attenuate pulmonary fibrosis, we hypothesized that IFN-gamma may regulate transforming growth factor ( TGF ) -beta production by airway epithelial cells ... IFN-gamma reduced basal and TGF-beta or IL-4 augmented TGF-beta2 release, but had little effect on IL-1beta- or PDGF augmented TGF-beta2 release ... The inhibitory effect of IFN-gamma on TGF-beta2 production was abrogated when the HBECs were treated with Smad 7 siRNA ... These results suggest that IFN-gamma down regulates TGF-beta2 production by HBECs by regulating Smad 7
Qi et al., Infect Immun 2004 (Leishmaniasis, Cutaneous) : The replication promoting effect of IFN-gamma on amastigotes was independent of the source and genetic background of Mphis, was apparently not affected by surface opsonization of amastigotes, was not mediated by interleukin-10 or transforming growth factor beta , and was observed at different temperatures
Langhorne et al., Immunol Rev 2004 (Inflammation...) : IFN-gamma and TNF-alpha play a role in both protective immunity and the pathology of the infection, and the inflammatory disease may be regulated by IL-10 and transforming growth factor-beta
Sashinami et al., Cytokine 2006 (Salmonella Infections, Animal) : Treatment of monoclonal antibodies against cytokines showed that IFN-gamma and interleukin 10 (IL-10) were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection, and IFN-gamma, TNF-alpha and transforming growth factor-beta ( TGF-beta ) were involved in maintenance of growth of this bacterium on day 30 after infection
Young et al., Immunity 2006 : Although transforming growth factor-beta ( TGF-beta ) inhibition of interferon-gamma (IFN-gamma) expression has been known for some time, in this issue of Immunity, the crosstalk between proinflammatory cytokine and TGF-beta signaling that regulates IFN-gamma expression is detailed for the first time
Yu et al., Immunity 2006 (Inflammation) : NK cells provide the antiinflammatory cytokine transforming growth factor ( TGF ) -beta , an autocrine/negative regulator of IFN-gamma
Nagineni et al., J Cell Physiol 2007 : Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway ... Under these conditions, the contrasting effects of IFN-gamma on TGF-beta1 and TGF-beta2 secretion were also observed ... JAK inhibitor selectively inhibited IFN-gamma induced TGF-beta1 secretion and mRNA levels while reversing the inhibitory effects of IFN-gamma on TGF-beta2
Burkart et al., Biochem Biophys Res Commun 2008 (Diabetes Mellitus, Type 1) : Hyperthermia induced Hsp70 expression was decreased by the T-helper 1-associated cytokine interferon-gamma and increased by the T-helper 2-associated transforming growth factor-beta
Sela et al., Immunology 2009 (Lupus Erythematosus, Systemic) : Upregulation of transforming growth factor-beta ( TGF-beta ) secretion by T cells, following treatment with hCDR1, resulted in downregulation of IFN-gamma production and contributed to the phenotypic changes and magnitude of IL-12 secretion by DCs
Lankat-Buttgereit et al., J Dermatol Sci 1991 : Interferon-gamma reduces all mRNA steady state levels dose dependently in comparison to the control, while transforming growth factor-beta simultaneously induces BM-40, alpha 1 and alpha 2 ( IV ) collagen mRNAs
Fitzner et al., Pancreatology 2009 (Autoimmune Diseases...) : IFN-gamma also caused pancreatic accumulation of CD4-, CD8-, C11b- and CD138 positive cells, and enhanced pancreatic mRNA expression of interleukin (IL)-1 beta, transforming growth factor-beta and IFN-gamma itself
Barnum et al., J Immunol 1994 (Inflammation) : In this report, we show that transforming growth factor-beta ( TGF-beta ) can significantly inhibit the capacity of IFN-gamma , IL-1 beta, and TNF-alpha to augment expression of the central component of complement C3 in the human astroglioma cell line D54-MG. Treatment of D54-MG cells with TGF-beta alone had no dose- or time dependent effect on basal C3 protein or mRNA levels
Offner et al., Am J Pathol 1996 : Neither tumor necrosis factor (TNF)-alpha nor interferon (IFN)-gamma ( both 10 ng/ml ) affected TGF-beta 1 or TGF-beta 2 synthesis by HPMCs. TGF-beta 3 could not be detected in any of the supernatant media
Spittler et al., Immunology 1997 : Both constitutive and interferon-gamma (IFN-gamma) , interleukin-4 (IL-4), IL-6 and tumour necrosis factor-alpha (TNF-alpha) induced human leucocyte antigen ( HLA ) -DR, HLA-DP and HLA-DQ Ag expression on monocytes was significantly down-regulated by calcitriol, IL-10 and transforming growth factor-beta ( TGF-beta )
Naganuma et al., Neurol Med Chir (Tokyo) 1996 (Brain Neoplasms...) : The effect of transforming growth factor-beta ( TGF-beta ) secreted by glioblastoma ( T98G ) cells on the secretion of interferon-gamma (IFN-gamma) by lymphokine activated killer ( LAK ) cells stimulated with tumor cells was investigated in cocultures of LAK and Daudi cells supplemented with T98G culture supernatant, T98G culture supernatant preincubated with anti-TGF-beta 1 and anti-TGF-beta 2 neutralizing antibodies, anti-TGF-beta 1 and anti-TGF-beta 2 antibodies, or natural human TGF-beta 1 or recombinant human TGF-beta 2