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EGFR — FGFR2
Text-mined interactions from Literome
Povlsen et al., J Neurochem 2008
:
Furthermore, NCAM-180 mediated
EGFR down-regulation requires NCAM homophilic binding and interactions of the cytoplasmic domain of NCAM-180 with intracellular interaction partners, but does not
require NCAM mediated
fibroblast growth factor receptor activation
Kunii et al., Cancer Res 2008
(Stomach Neoplasms) :
We show that the elevated
EGFR , Her2, and Erbb3 phosphotyrosine is
dependent on
FGFR2 , revealing EGFR family kinases to be downstream targets of amplified FGFR2
Miraoui et al., Hum Mol Genet 2010
(Acrocephalosyndactylia) :
Investigation of the underlying molecular mechanisms revealed that activated
FGFR2 enhances
EGFR and PDGFRalpha mRNA expression via activation of PKCalpha dependent AP-1 transcriptional activity
Ware et al., PloS one 2010
(Carcinoma, Non-Small-Cell Lung...) :
Moreover, inhibitors of c-Src and MEK stimulated fgfr2-luc activity to a similar degree as gefitinib, suggesting that these pathways may mediate
EGFR dependent repression of
FGFR2 and FGFR3