Gene interactions and pathways from curated databases and text-mining

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EGFR — FGFR2

Text-mined interactions from Literome

Povlsen et al., J Neurochem 2008 : Furthermore, NCAM-180 mediated EGFR down-regulation requires NCAM homophilic binding and interactions of the cytoplasmic domain of NCAM-180 with intracellular interaction partners, but does not require NCAM mediated fibroblast growth factor receptor activation
Kunii et al., Cancer Res 2008 (Stomach Neoplasms) : We show that the elevated EGFR , Her2, and Erbb3 phosphotyrosine is dependent on FGFR2 , revealing EGFR family kinases to be downstream targets of amplified FGFR2
Miraoui et al., Hum Mol Genet 2010 (Acrocephalosyndactylia) : Investigation of the underlying molecular mechanisms revealed that activated FGFR2 enhances EGFR and PDGFRalpha mRNA expression via activation of PKCalpha dependent AP-1 transcriptional activity
Ware et al., PloS one 2010 (Carcinoma, Non-Small-Cell Lung...) : Moreover, inhibitors of c-Src and MEK stimulated fgfr2-luc activity to a similar degree as gefitinib, suggesting that these pathways may mediate EGFR dependent repression of FGFR2 and FGFR3