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AREG — EGFR

Pathways - manually collected, often from reviews:

• KEGG ErbB signaling pathway: AREG → Complex of EGFR (protein-protein, activation)
• KEGG ErbB signaling pathway: AREG → EGFR (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — AREGB, AREG (direct interaction, pull down) Wong et al., J Biol Chem 1999*
• IRef Dip Interaction: EGFR — AREGB, AREG (physical association, affinity chromatography technology) Wong et al., J Biol Chem 1999*
• IRef Dip Interaction: EGFR — AREGB, AREG (physical association, biochemical) Thompson et al., J Biol Chem 1996*
• IRef Hprd Interaction: EGFR — AREGB, AREG (in vivo) Wong et al., J Biol Chem 1999*
• IRef Ophid Interaction: EGFR — AREGB, AREG (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Basbaum et al., Novartis Found Symp 2002 : The mode of activation of EGFR in response to bacterial lipoteichoic acid involves cleavage of the transmembrane ligand HBEGF by ADAM 10, whereas the activation of EGFR in response to smoke involves cleavage of amphiregulin by ADAM 17
Schäfer et al., Oncogene 2004 (Neoplasm Invasiveness...) : Moreover, we report that the EGFR transactivation signal involves the EGFR ligands amphiregulin , HB-EGF and TGFalpha as well as the metalloproteinases ADAM 10, 15 and 17, depending on the cellular system
Koon et al., J Biol Chem 2004 : Pretreatment with antibodies against potential EGFR ligands suggested that transforming growth factor-alpha ( TGFalpha ), but not the other EGFR ligands EGF, heparin binding EGF, or amphiregulin , mediates SP-induced EGFR transactivation
Kansra et al., Mol Pharmacol 2005 : Src family kinase inhibitors block amphiregulin mediated autocrine ErbB signaling in normal human keratinocytes ... The ErbB inhibitor PD158780 and the mitogen activated protein kinase kinase inhibitor U0126 also markedly inhibited NHK proliferation, migration, and amphiregulin production
Mahtouk et al., Oncogene 2005 (Multiple Myeloma) : Using real-time reverse transcriptase-polymerase chain reaction, we found that MM cells expressed ErbB receptors and that AREG promoted their growth
Gilmore et al., Breast Cancer Res Treat 2008 (Breast Neoplasms) : Taken together, it appears that autocrine stimulation of EGFR signaling by amphiregulin is coupled to PTHrP gene expression via EGFR Tyr992 and MAPK, and that this pathway may contribute to PTHrP expression by breast tumor cells
Willmarth et al., J Mammary Gland Biol Neoplasia 2008 (Breast Neoplasms...) : Activation of the EGFR by amphiregulin can occur through autocrine, paracrine and juxtacrine mechanisms
Sternlicht et al., J Mammary Gland Biol Neoplasia 2008 (Breast Neoplasms) : Thus proper mammary morphogenesis requires the ADAM17 mediated release of AREG from ductal epithelial cells, the subsequent activation of EGFR on stromal cells, and EGFR dependent stromal responses that in return elicit a new set of epithelial responses, all culminating in the formation of a fully functional ductal tree
Rodland et al., J Biol Chem 2008 (MAP Kinase Signaling System) : Instead, IGF-1 appeared to work by enhancing EGFR activation of Ras in response to constitutively produced amphiregulin
Singh et al., Int J Cancer 2009 (Skin Neoplasms) : Furthermore, using neutralizing antibodies we found that proligand amphiregulin was required for UV-induced EGFR activation in SCC-9 cells
Stoll et al., J Invest Dermatol 2010 : EGFR ligand expression in normal skin was low ( < 8 per thousand of RPLP0/36B4 ) ; however, HB-EGF and AREG mRNAs were strongly induced in human skin organ culture
Kasina et al., Cell Prolif 2009 : ADAM mediated amphiregulin shedding and EGFR transactivation
Baillo et al., J Cell Physiol 2011 (Inflammatory Breast Neoplasms...) : We also demonstrated that AREG can increase epidermal growth factor receptor (EGFR) stability and promote EGFR localization to the plasma membrane
Bade et al., J Cell Sci 2011 (Breast Neoplasms...) : Here, we investigated whether the FGFR1 induced increase in AREG and EREG expression might coordinately increase EGFR signaling to promote mammary tumorigenesis ... Taken together, these data suggest that AREG and EREG mediate tumorigenic phenotypes by activating EGFR signaling, and that the oncogenic potential of FGFR1 requires EGFR activation to promote mammary tumorigenesis
Manzo et al., Am J Respir Cell Mol Biol 2012 (Lung Injury...) : Mice deficient in AREG and lung epithelial EGFR were used to define roles for AREG dependent EGFR signaling in airway repair and remodeling ... Our data demonstrate that AREG dependent EGFR signaling in airway epithelial cells contributes to MCM in naphthalene induced lung injury
Sehgal et al., Mol Biol Cell 1994 (Breast Neoplasms...) : Epidermal growth factor receptor dependent stimulation of amphiregulin expression in androgen stimulated human prostate cancer cells ... We also show that ligand dependent EGF-R stimulation induces amphiregulin expression and that androgenic effects on amphiregulin synthesis are mediated through this EGF-R pathway