◀ Back to TNF
MUC5AC — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Takeyama et al., Proc Natl Acad Sci U S A 1999
(Hyperplasia) :
EGF-R ligands increased the expression of
MUC5AC at both gene and protein levels, and this effect was
potentiated by
TNFalpha
Enss et al., Inflamm Res 2000
(Intestinal Neoplasms) :
Immunocytochemistry and Western blotting confirmed
TNFalpha effects on MUC2 and
MUC5AC on the protein levels
Smirnova et al., Cytokine 2000
:
TNF-alpha stimulates
MUC5AC mucin secretion in a dose dependent manner, with 20 ng/ml producing maximal stimulation
Smirnova et al., Eur Cytokine Netw 2001
:
To determine the
effect of IL-6 and
TNF-alpha on
MUC5AC and MUC5B secretion we have used HT29-MTX goblet cells, which secrete both types of mucins ... IL-6 and
TNF-alpha stimulated
MUC5AC and MUC5B mucin secretion in a time dependent manner, both in pre-confluent and post-confluent cells
Zen et al., Am J Pathol 2002
(Liver Diseases) :
TNF-alpha alone also
induced the overexpression of MUC2 and
MUC5AC in cultured biliary epithelial cells
Song et al., J Biol Chem 2003
(Inflammation...) :
Interleukin-1 beta and
tumor necrosis factor-alpha induce
MUC5AC overexpression through a mechanism involving ERK/p38 mitogen activated protein kinases-MSK1-CREB activation in human airway epithelial cells ... However, the mechanisms by which the interleukin (IL)-1beta and
tumor necrosis factor (TNF)-alpha induce
MUC5AC gene expression in normal nasal epithelial cells, and the signal molecules involved, especially in the downstream signaling of mitogen activated protein ( MAP ) kinases, remain unclear ... Here we show that pharmacologic or genetic inhibition of either ERK or p38 MAP kinase pathway abolished IL-1beta- and
TNF-alpha induced
MUC5AC gene expression in normal human nasal epithelial cells ... Taken together, these studies give additional insights into the molecular mechanism of IL-1beta- and
TNF-alpha induced
MUC5AC gene expression and enhance our understanding on mucin hypersecretion during inflammation
Gray et al., Mol Pharmacol 2004
:
We also observed that
tumor necrosis factor (TNF)-alpha , platelet activating factor (PAF), and lipopolysaccharide (LPS)
induced COX-2 and increased
MUC5AC production that was blocked by celecoxib, suggesting a common signaling pathway of inflammatory mediator induced MUC5AC production in NHTBE cells ... We conclude that the
induction of
MUC5AC by IL-1beta,
TNF-alpha , PAF, and LPS involves COX-2- generated PGE ( 2 ), activation of EP2 and/or EP4 receptor ( s ), and cAMP-PKA mediated signaling
Young Kim et al., Acta Otolaryngol 2004
(Chronic Disease...) :
Extracellular signal regulated kinase is involved in
tumor necrosis factor-alpha induced
MUC5AC gene expression in cultured human nasal polyp epithelial cells ... We then examined whether
tumor necrosis factor-alpha (TNF-alpha) induces
MUC5AC gene expression and whether extracellular signal regulated kinase ( ERK ) plays a role in TNF-alpha induced MUC5AC gene expression in cultured human nasal polyp epithelial cells ...
TNF-alpha induced
MUC5AC gene expression, and ERK activation was found to be essential for TNF-alpha induced MUC5AC gene expression in cultured human nasal polyp epithelial cells ...
TNF-alpha induces
MUC5AC gene expression via ERK in cultured human nasal polyp epithelial cells
Hauber et al., J Allergy Clin Immunol 2005
(Chronic Disease...) :
TNF-alpha significantly
increased MUC5AC and hCLCA1 mRNA as well as mucus and hCLCA1 protein expression in the mucosal explant tissue ( P < .05 )
Ishibashi et al., Glycoconj J 2005
(Lung Neoplasms) :
TNF-alpha induced expression of hST3GalIV, FUT3, C2/4GnT and
MUC5AC mRNAs in NCI-H292 cells
Antonela Antoniu et al., Expert Opin Investig Drugs 2009
:
Both LPS and
TNF-alpha increased
MUC5AC mucin production in vivo and in vitro, respectively, and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene
Busse et al., Ann Allergy Asthma Immunol 2009
(Asthma) :
TNF-alpha induced
MUC-5AC expression in human airway culture significantly decreased with pretreatment of a NF-kappaB inhibitor
Oslund et al., Am J Vet Res 2010
(Airway Obstruction...) :
Data suggested that a nuclear factor KB-based transcriptional mechanism is involved in
induction of
MUC5AC expression by
tumor necrosis factor-A
Lee et al., Am J Respir Cell Mol Biol 2011
:
Because MUC5AC expression is known to be up-regulated by TNF-a via NF-?B activation, we evaluated the inhibitory effect of a-MSH on
MUC5AC gene expression
induced by
TNF-a in normal human nasal epithelial ( NHNE ) cells ... Real-time quantitative PCR data showed that a-MSH inhibited
TNF-a induced expression of
MUC5AC , and this effect of a-MSH was neutralized by knockdown of MC-1R using MC-1R shRNA lentivirus
Yu et al., Zhonghua Yi Xue Za Zhi 2011
:
[ Regulation of sphingosine kinase 1 in the
TNF-a induced expression of
MUC5AC in airway epithelial cells ]