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TLR1 — TLR3
Text-mined interactions from Literome
Harii et al., Mol Endocrinol 2005
(Thyroiditis, Autoimmune...) :
We conclude that functional TLR3 are present on thyrocytes
; TLR3 downstream signals can be overexpressed by pathogen related stimuli ; overexpression can be reversed by phenylmethimazole to a significantly greater extent than MMI by inhibiting only the IFN regulatory factor-3/IFN-beta/signal transducers and activation of transcription arm of the TLR3 signal system ; and
TLR3 overexpression can
induce an innate immune response in thyrocytes, which may be important in the pathogenesis of Hashimoto 's thyroiditis and in the immune cell infiltrates
Sel et al., J Immunol 2007
(Asthma...) :
These data indicate that
TLR-3 or TLR-7
activation by viral
TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10
Bayas et al., Clin Exp Immunol 2009
(Bacterial Infections...) :
In peripheral blood mononuclear cells,
TLR-9 stimulation with type A CpG ODN
resulted in a higher expression of
TLR-1 , -2, -4, -5 and -8 in MS patients ( n = 7 ) compared with healthy controls ( n = 11 )
Goethals et al., Glia 2010
(Wallerian Degeneration) :
Upon axotomy,
TLR1 becomes strongly
induced , while most other
TLR expression levels remain unaffected
Yang et al., Bing Du Xue Bao 2011
(Marek Disease...) :
By comparing the TLRs transcription between YL040920 and CVI988/Rispens infected microglia, it was suggested that vvMDV YL040920 might
induce more
TLR15 transcript than the attenuated vaccine strain CVI988/Rispens ( P < or = 0.01/0.001 ), while CVI988/Rispens induced more
TLR1LB transcript than YL040920 ( P < or = 0.001 )
Raicevic et al., Tissue Eng Part A 2012
:
Inflammation was mimicked by a cytokine cocktail, and
TLR activation was
induced through
TLR3 and TLR4 ligation
Melkamu et al., Journal of cell communication and signaling 2013
:
These findings demonstrate that
TLR3 activation differentially
regulates TLR expression through autocrine signaling involving IL-6 secretion, IL-6Ra activation and subsequent phosphorylation of Stat3