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IL24 — STAT1
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and
STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999
:
Interestingly,
interleukin (IL)-7 selectively
activated STAT1 and induced MHC class I in mature T but not B cells
Wang et al., Immunology 2005
(Neoplasms...) :
Upon binding to its receptors,
IL-24 induces rapid activation of
Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation
Kreis et al., PloS one 2007
(Melanoma) :
Binding of
IL-24 to either of its two possible heterodimeric receptors IL-20R1/IL-20R2 and IL-22R/IL-20R2
activates STAT3 and/or
STAT1 in target tissues such as lung, testis, ovary, keratinocytes and skin