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AKT2 — STAT1

Text-mined interactions from Literome

Nguyen et al., J Biol Chem 2001 : We show that phosphatidylinositol 3-kinase (PI3K) and its effector kinase Akt play an important role in the serine phosphorylation of STAT1 and in the activation of gene expression in response to interferon-gamma (IFN gamma) ... Constitutively active forms of PI3K or Akt activate and their dominant negative derivatives inhibit STAT1-driven transactivation in response to IFN gamma
Duensing et al., Oncogene 2004 (Gastrointestinal Neoplasms) : Using GIST in vitro models, we showed that activation of MAPK p42/44, AKT , and S6K was KIT dependent , whereas STAT1 and STAT3 phosphorylation was only partially dependent on KIT activation
Venkatesan et al., Cell Signal 2006 : These data provide the first evidence that PI 3 kinase dependent Akt and PKCepsilon activation independently regulate MAPK activity and serine phosphorylation of STAT1alpha to increase expression of MCP-1
Rosner et al., Am J Pathol 2006 (Atherosclerosis) : IFN-gamma also stimulated Akt activity, and both Fas trafficking and Stat1 activation were inhibited by blocking PI3K, Akt, or Jak-2
Ghosh et al., Chem Biol Interact 2009 (Disease Models, Animal...) : Investigating the cell signaling pathways, we found that the protein exerts its protective action via the activation of NF-kappaB and Akt and deactivation of STAT-1
Wei et al., Am J Transplant 2010 : We show that IFN-gamma production and STAT1 activation was increased, while STAT1 dependent PKB/AKT activation was downregulated in alloantigen reactive Tregs
Wang et al., Biochem Biophys Res Commun 2012 (Carcinoma, Hepatocellular...) : Moreover, sorafenib inhibited IFN-a induced oncogenic signaling of STAT3, AKT and ERK but not the activation of the tumor suppressor STAT1