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ELMO1 — RAC3

Text-mined interactions from Literome

Brugnera et al., Nat Cell Biol 2002 : In cells, binding of Dock180 to Rac alone is insufficient for GTP loading, and a Dock180 ELMO1 interaction is required ... We can also detect a trimeric ELMO1 Dock180 Rac1 complex and ELMO augments the interaction between Dock180 and Rac
Lu et al., Methods Enzymol 2006 : The best characterized is the Rac activation by the Dock180-ELMO complex
Tosello-Trampont et al., Cell Death Differ 2007 : Although the role of ELMO : Dock180 in regulating Rac activation has been well defined, the function of CED-2/CrkII in this complex is less well understood
Komander et al., Mol Biol Cell 2008 : Significantly, although this does not affect DOCK180 GEF activity toward Rac in vivo, Rac signaling is impaired, implying additional roles for ELMO in mediating intracellular Rac signaling
Fritsch et al., Cell 2013 (Fibrosis) : In fibroblasts, GPCRs couple to PI3K through Dock180/Elmo1 mediated RAC activation and subsequent interaction with p110ß