Gene interactions and pathways from curated databases and text-mining

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NOS3 — PPP1R3A

Text-mined interactions from Literome

Leung et al., FEBS Lett 2006 : Rg1 increased the phosphorylation of GR, phosphatidylinositol-3 kinase (PI3K), Akt/PKB and endothelial nitric oxide synthase (eNOS) leading to increase nitric oxide ( NO ) production in human umbilical vein endothelial cell ... Rg1 induced eNOS phosphorylation and NO production were significantly reduced by RU486, LY294,002, or SH-6
Yang et al., Acta Biochim Biophys Sin (Shanghai) 2012 (Diabetes Mellitus, Experimental...) : Accumulating data have suggested that Rg1 , a main component of Panax ginseng, has the ability to promote tubulogenesis of human umbilical vein endothelial cells ( HUVECs ) in vitro, and that the mechanism involves increased expression level of VEGF as well as increased eNOS activation