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ARF5 — MYC
Text-mined interactions from Literome
Qi et al., Nature 2004
(Cell Transformation, Neoplastic) :
Here we show that
ARF can
inhibit c-Myc by a unique and direct mechanism that is independent of p53
Dang et al., Cancer Cell 2005
(Burkitt Lymphoma...) :
Acute
MYC expression
increases p53 or
ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc induced lymphomas
Li et al., Cell cycle (Georgetown, Tex.) 2009
:
Whereas loss of
ARF accelerates
c-Myc induced tumorigenesis, NPM overexpression enhances c-Myc transformation
Li et al., Oncogene 2013
:
Here, we show that NPM is necessary for the localization of c-Myc protein to nucleoli, whereas
c-Myc nucleolar localization is
independent of p53, Mdm2 and
ARF
Zhang et al., Proc Natl Acad Sci U S A 2013
(Cell Transformation, Neoplastic) :
ARF inhibits the interaction of
c-Myc with the E3 ubiquitin ligase Skp2
Chen et al., Mol Cell 2013
:
Although the mRNA levels of ARF are induced in both scenarios, the accumulation of ARF protein occurs only when ULF mediated degradation of
ARF is
inhibited by
c-Myc overexpression