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MAPK11 — MEF2C
Pathways - manually collected, often from reviews:
-
KEGG MAPK signaling pathway:
MAPK11/MAPK12/MAPK13/MAPK14
→
MEF2C
(protein-protein, phosphorylation)
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NCI Pathway Database Signaling mediated by p38-alpha and p38-beta:
p38alpha-beta-active (MAPK14/MAPK11)
→
MEF2C (MEF2C)
(modification, activates)
Han et al., Nature 1997, Zhao et al., Mol Cell Biol 1999
Evidence: mutant phenotype, assay
-
Reactome Reaction:
MEF2C
→
MAPK11
(reaction)
Yang et al., Mol Cell Biol 1999, Wu et al., Mol Cell Biol 2000, Han et al., Nature 1997, Zhao et al., Mol Cell Biol 1999, Zetser et al., J Biol Chem 1999
-
Reactome Reaction:
MEF2C
→
MAPK11
(direct_complex)
Yang et al., Mol Cell Biol 1999, Wu et al., Mol Cell Biol 2000, Han et al., Nature 1997, Zhao et al., Mol Cell Biol 1999, Zetser et al., J Biol Chem 1999
Text-mined interactions from Literome
Ding et al., Stem Cells Dev 2008
:
Nuclear location of
MEF2C , which played a critical role in cardiomyocyte differentiation and could be
activated by
p38MAPK , was stimulated after icariin exposure
Andrews et al., Eur J Immunol 2012
:
The transcription factor
myocyte enhancer factor-2C (MEF2C) is
regulated by both calcineurin and
mitogen activated protein kinase signaling pathways, and is essential for proliferation and survival downstream of BCR engagement in mature B cells