◀ Back to LEP
LEP — SST
Text-mined interactions from Literome
Tan et al., Clin Endocrinol (Oxf) 2001
(Acromegaly) :
We have evaluated the effect of Sandostatin LAR on leptin levels in acromegalic patients since there are recent data to suggest that
somatostatin , in addition to its GH lowering effect, also
reduces serum
leptin levels in humans
Goïot et al., Gastroenterology 2001
:
The
effects of
leptin on gastrin messenger RNA ( mRNA ), plasma gastrin, gastric acid in vivo in the rat, and on
somatostatin and gastrin secretions by isolated antral cells were determined in vitro ... Isolated antral cells specifically bound [ ( 125 ) I ]
-leptin , and addition of leptin to these cells
inhibited the release of
somatostatin and increased the release of gastrin
Watanobe et al., J Neurosci 2002
:
Leptin regulates growth hormone releasing factor,
somatostatin , and alpha-melanocyte stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo : relation with growth hormone secretion ... However, no previous study examined in vivo whether
leptin affects the secretion of GH-releasing factor (GRF),
somatostatin ( SRIH ), and some other closely relevant neurohormones in the hypothalamus
Rigamonti et al., Metabolism 2012
(Obesity...) :
Somatostatin ( SRIF )
inhibits circulating levels of adiponectin and
leptin in lean ( LN ) subjects, but the effect of a SRIF infusion on these adipokines, including TNF-a, in OB is to date unknown
Perianes-Cachero et al., Neurochem Int 2012
:
As
leptin and its receptors are expressed in the hippocampus and
somatostatin ( SRIF ), an orexigenic neuropeptide, may
inhibit leptin mediated suppression of food intake in other brain areas, we asked whether chronic leptin infusion induces changes in the hippocampal somatostatinergic system and whether these modifications are involved in leptin mediated effects
Quintela et al., Endocrinology 1997
:
Leptin inhibits in vitro hypothalamic somatostatin secretion and
somatostatin mRNA levels ... In order to further unravel the mechanisms by which leptin acts, we have studied the
effect of
leptin on in vitro
somatostatin synthesis and secretion ... Finally,
leptin ( 3x10 ( -8 ) M M ) also
inhibited low glucose ( 1.1 mM )
induced-somatostatin secretion in perifused adult hypothalami
Donahoo et al., J Clin Endocrinol Metab 1997
:
Therefore both isoproterenol and
somatostatin reduce plasma
leptin in humans
Leclercq-Meyer et al., Mol Cell Endocrinol 1998
(Body Weight) :
Failure of human and mouse
leptin to
affect insulin, glucagon and
somatostatin secretion by the perfused rat pancreas at physiological glucose concentration
Tannenbaum et al., Endocrinology 1998
(Body Weight) :
The results suggest that the GH-releasing activity of
leptin is
mediated , at least in part, by an inhibition of hypothalamic
somatostatin release