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IL6 — TNFSF11

Text-mined interactions from Literome

Josien et al., J Immunol 1999 : In DCs, TRANCE induces the expression of proinflammatory cytokines ( IL-6 , IL-1 ) and T cell growth and differentiation factors ( IL-12, IL-15 ) in addition to enhancing DC survival
O'Brien et al., J Biol Chem 1999 : Moreover, dn-STAT3 blocked the ability of either IL-6 + soluble IL-6 receptor or oncostatin M to induce RANKL
Hofbauer et al., Bone 1999 : By northern analysis, IL-1beta ( 5 nmol/L ) and TNF-alpha ( 9 nmol/L ) increased OPG-L mRNA steady-state levels by up to two- to three-fold in normal marrow stromal cells ( MS ), an immortalized marrow stromal cell line ( hMS ), and the osteosarcoma cell line, MG-63, whereas IL-6 ( 2 nmol/L, with or without its soluble receptor ) had no effect on OPG-L mRNA levels in any of these cells
Giuliani et al., Blood 2002 (Multiple Myeloma...) : In addition, either anti-interleukin 6 ( anti-IL-6 ) or anti-IL-7 antibody inhibited HMCL induced RANKL overexpression
Sieghart et al., Wien Med Wochenschr 2004 (Fractures, Spontaneous...) : increased sensitivity of osteoclast-precursors to 1,25 ( OH ) 2Vitamin D3 and RANKL , mediated by IL6 have been described as a possible mechanism
Giuliani et al., Haematologica 2004 (Multiple Myeloma) : Consistently, RANKL did not have a direct effect on myeloma cell survival, but RANKL treatment induced a significant increase of interleukin (IL)-6 and IL-11 secretion by both BMSC and endothelial cells
O'Brien et al., Am J Physiol Endocrinol Metab 2005 (Bone Resorption...) : IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice
Shaarawy et al., J Soc Gynecol Investig 2005 (Bone Resorption...) : The increased osteoclastic activity in preeclampsia may be attributed to increased RANKL induced by increased interleukin-6 (IL-6) , tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor beta2 ( TGF-beta2 ) production
Park et al., Exp Mol Med 2005 : In addition, RANKL increased the expression of TNFalpha, MCP-1, and IL-6 but not of IL-10, IL-12, IFN-gamma, and iNOS
Lamothe et al., J Biol Chem 2008 : Additionally, expression of TRAF6 lacking ZF2-4 in TRAF6-deficient monocytes rescues RANKL mediated osteoclast differentiation and LPS stimulated interleukin-6 production
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : IL-6 trans signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17 ... RANKL expression was induced by IL-6/sIL-6R ( but not IL-6 alone ) and by IL-1beta ... On the other hand, TNF-alpha and IL-17 did not induce RANKL expression, although TNF-alpha, IL-17 or IL-1beta stimulated cell growth and IL-6 production ... PAR completely inhibited IL-6/sIL-6R induced RANKL expression, but PD did not ... IL-6/sIL-6R directly induced RANKL expression in RA-FLS and it is essential for RANKL induction by TNF-alpha and IL-17 ... Moreover, RANKL induction by IL-6/sIL-6R is mediated by the janus kinase/STAT signalling pathway
Suzuki et al., Clin Exp Immunol 2011 : IL-6+sIL-6R treatment significantly induced RANKL production in SW982 cells, and anti-RANKL antibody inhibited IL-6+sIL-6R induced osteoclastogenesis
Noh et al., Life Sci 2011 (Bone Resorption) : While the RANKL stimulated induction of IL-1ß and IL-6 was not affected, TNF-a induction was reduced by BayK 8644 treatment
Kaneko et al., J Clin Endocrinol Metab 2012 (Autoimmune Diseases) : Up-regulation of RANKL and OPG mRNA by IL-6 was suppressed by dexamethasone
Zheng et al., Biochem Pharmacol 2013 (Bone Resorption) : Coumermycin A1 also abrogated RANKL induced expression of interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments