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IL12RB2 — IL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhang et al., J Interferon Cytokine Res 2000
:
Corrective
effects of
interleukin-12 on age related deficiencies in IFN-gamma production and
IL-12Rbeta2 expression in virus-specific CD8+ T cells
Wu et al., Eur J Immunol 2000
:
Using an antibody specific for the human IL-12Rbeta2 subunit, the
effect of IFN-gamma, IFN-alpha, IL-12 and
IL-2 on the regulation of
IL-12R expression and IL-12 responsiveness of human T and NK cells was assessed
Elloso et al., Eur J Immunol 2001
:
IL-2 could
restore IL-12R expression to CD28 ( -/- ) CD4 ( + ) cells, however, this occurred independently of IL-2 induced proliferation
Makrigiannis et al., J Leukoc Biol 2001
:
IL-2 is
required for
IL-12Rbeta2 expression by T cells activated in the presence of anti-CD86 mAb ... We, therefore, conclude that the ability of IL-12 to substitute for CD28-costimulatory signaling during CTL development is a result of the interaction of IL-12 with
IL-12Rbeta2 induced by low levels of
IL-2 synthesized by T cells activated in a CD28 independent manner
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha,
IL-2 , and IL-10 secretion
Fujimiya et al., Clin Cancer Res 1997
(Brain Neoplasms...) :
Thus, the increased expression of the IL-2Rbeta is critical for the synergistic activation of gammadelta T cells by IL-12 plus IL-2 ; it is also probable that at least the low-affinity
IL-12R contributes to the activation of gammadelta T cells mediated by either IL-12 alone or IL-12 plus
IL-2