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CTNNB1 — KLF4

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → KLF4 (KLF4) (modification, collaborate) Evans et al., Mol Cell Biol 2010
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4) (modification, collaborate)
  Evans et al., Mol Cell Biol 2010
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: KLF4 (KLF4) → TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4) (modification, collaborate)
  Evans et al., Mol Cell Biol 2010
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4) (modification, collaborate)
  Lévy et al., Mol Cell Biol 2004, Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: p300 (EP300) → TCF4/beta catenin/KLF4 complex (TCF7L2-CTNNB1-KLF4) (modification, collaborate)
  Lévy et al., Mol Cell Biol 2004, Ma et al., Oncogene 2005, Miyabayashi et al., Proc Natl Acad Sci U S A 2007, Evans et al., Mol Cell Biol 2010
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999

Text-mined interactions from Literome

McConnell et al., Cancer Res 2009 (Adenoma...) : Thus, KLF5 is necessary for the tumor initiating activity of beta-catenin during intestinal adenoma formation in Apc ( Min/+ ) mice, and reduced expression of KLF5 offsets the tumor initiating activity of the Apc ( Min ) mutation by reducing the nuclear localization and activity of beta-catenin
Evans et al., Mol Cell Biol 2010 : In this study, we characterize the molecular mechanisms of KLF4 mediated inhibition of Wnt/beta-catenin signaling