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Ruefli et al., Int J Cancer 2002
(Colonic Neoplasms...) :
These data provide evidence that P-gp inhibits caspase activation after chemotherapeutic drug treatment and demonstrates that SAHA may be of value for the treatment of P-gp expressing MDR cancers
Ruefli et al., Cell Death Differ 2002
:
The ability of P-gp to inhibit caspase-8 activation was also ATP dependent ... These studies demonstrate that P-gp inhibits Fas induced caspase-8 activation but not formation of the DISC and that this activity of P-gp is dependent on ATP hydrolysis
Bárcia et al., Immunobiology 2003
:
Recent findings suggest that Pgp may be involved in regulating programmed cell death by inhibiting caspase 8 and caspase 3
Seo et al., Molecular cancer 2010
:
Moreover, TRAIL inhibited P-gp efflux function via caspase-3 dependent degradation of P-gp as well as DNA-PKcs and subsequently sensitized MDR cells to MDR related drugs such as vinblastine and doxorubicin
Smyth et al., Proc Natl Acad Sci U S A 1998
(Leukemia, T-Cell) :
Inhibition of P-gp function also enhanced drug or Fas mediated activation of caspase-3 in drug-resistant CEM cells