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Text-mined interactions from Literome

Kang et al., Br J Pharmacol 2009 : This study aims to clarify effects of LDL on activation of HSC , to evaluate roles of curcumin in suppressing these effects and to further elucidate the underlying molecular mechanisms ... LDL stimulated HSC activation in vitro, which was attenuated by curcumin ... Curcumin suppressed LDLR gene expression in activated HSCs in vitro by activating PPARgamma and differentially regulating gene expression of SREBPs, reducing cellular cholesterol and attenuating the stimulatory effects of LDL on HSC activation ... These results provide novel insights into the roles and mechanisms of curcumin in the inhibition of LDL induced HSC activation
Kang et al., Endocrinology 2009 : These results provide novel insights into molecular mechanisms by which curcumin inhibits LDL induced HSC activation