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ANGPT2 — CCL2

Text-mined interactions from Literome

Kashiwagi et al., Nephron 2002 (Body Weight) : Furthermore, it is also indicated that Ang II stimulates MCP-1 expression via Ang II type 1 receptor, whereas RANTES expression is mediated via Ang II type 2 receptor
Wu et al., Mol Endocrinol 2004 : Ang II stimulation induced MCP-1 mRNA expression as well as an increase in nuclear factor-kappaB (NF-kappaB) binding to the corresponding cis DNA element of the MCP-1 promoter region and a decrease in the cytosolic inhibitory protein-kappaB ( IkappaB ) protein level via AT(1) receptor stimulation, whereas stimulation of the AT(2) receptor decreased Ang II-induced MCP-1 expression, NF-kappaB DNA binding, and IkappaB degradation, suggesting that activation of the AT(2) receptor attenuated AT(1) receptor mediated MCP-1 expression via a decrease in NF-kappaB DNA binding and an increase in IkappaB stability
Weisberg et al., Arterioscler Thromb Vasc Biol 2005 (Aortic Diseases...) : Ang II increased aortic mRNA expression of PAI-1, collagen I, collagen III, fibronectin, osteopontin, monocyte chemoattractant protein-1 , and F4/80 ; PAI-039 significantly decreased the Ang II-induced increase in aortic osteopontin expression at 8 weeks
Kanno et al., Dig Dis Sci 2005 (Hepatitis...) : These results suggest that Ang II modulates hepatic inflammation via production of MCP-1 by hepatic stellate cells, and the effect of Ang II on MCP-1 production is, at least partly, mediated by the Rho/Rho-kinase pathway
Xie et al., Int J Cardiol 2006 (Hypertension, Renovascular) : These findings imply Ang II may be involved in facilitating MCP-1 production in hypertension, and may provide a molecular link between hypertension and the development of atherosclerosis
Mateo et al., J Immunol 2006 : Stimulation of human endothelial cells ( human umbilical arterial endothelial cells and HUVECs ) with 1-1000 nM Ang-II , predominantly acting at its AT(1) receptor, induced the release of MCP-1 within 1 h, RANTES within 4 h, and MCP-3 within 24 h. Eotaxin-3, a natural CCR2 antagonist, was released within 1 h and may delay mononuclear cell responses to MCP-1
Tsuchiya et al., Am J Physiol Endocrinol Metab 2006 (Obesity) : In conclusion, our present study demonstrates that ANG II increases MCP-1 gene expression via ANG II type 1 receptor mediated and NF-kappaB dependent pathway in rat preadipocytes as well as adipose MCP-1 expression in vivo
Mateo et al., Blood 2007 : Neutralization of TNFalpha activity reduced Ang-II induced MCP-1 , MCP-3, and RANTES release from HUAECs and MIP-1alpha from blood cells
Zhang et al., Cardiovasc Pathol 2007 (Carotid Artery Injuries...) : Ang II not only increased MCP-1 and MIP-1alpha production but also enhanced neo-intimal formation, media thickness, and adventitia development in the ligated carotid arteries in C57BL/6 mice
Abu Nabah et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : Ang-II increased HUAEC CXCR2 expression, and its blockade caused a significant reduction of MCP-1 , -3, and RANTES release, as well as mononuclear cell arrest
Takahashi et al., Am J Physiol Heart Circ Physiol 2008 (Disease Models, Animal...) : These results suggested that ANG II and TNF-alpha synergistically stimulate MCP-1 expression via the utilization of distinct intracellular signaling pathways ( p38- and NFkappaB dependent pathways ) and that these pathways are activated in ROS dependent and -independent manners
Duerrschmid et al., J Mol Cell Cardiol 2013 (Cardiomegaly...) : Ang-II induces the synthesis of monocyte chemoattractant protein-1 that mediates the uptake of CD34CD45 monocytic cells into the heart
Chen et al., Circ Res 1998 : Ang II also activated MCP-1 gene transcription