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MUC1 — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Gao et al., Int J Oncol 2009
(Carcinoma, Non-Small-Cell Lung...) :
STAT3 knockdown downregulated MUC1 expression whereas constitutive
STAT3 expression
increased MUC1 expression at mRNA and protein levels ... These results demonstrate that constitutively activated
STAT3 regulates expression of
MUC1 , which mediates lung cancer cell survival and metastasis in vitro and in vivo
Ahmad et al., Science signaling 2011
:
The MUC1-C cytoplasmic domain interacted directly with JAK1 and STAT3, and
MUC1-C was
necessary for JAK1 mediated
STAT3 activation ... In turn, MUC1-C and activated
STAT3 occupied the promoter of MUC1, and MUC1-C
contributed to STAT3 mediated activation of
MUC1 transcription ... These findings indicate that
MUC1-C promotes
STAT3 activation and that MUC1-C and STAT3 function in an autoinductive loop that may play a role in cancer cell survival