◀ Back to NOS3

NOS3 — RHO

Text-mined interactions from Literome

Laufs et al., Med Klin (Munich) 1999 : Upregulation of eNOS by inhibiting Rho may provide a new pharmacologic target for the treatment of arteriosclerosis, pulmonary hypertension, and heart failure
Boer et al., Am J Physiol Heart Circ Physiol 2002 : We studied the amplitude and response time ( RT ; time to 50 % of maximal response ) of pulmonary vasoreactivity and investigated whether the characteristics of pulmonary vasoreactivity could be modulated by endothelium removal, nitric oxide ( NO ) synthase inhibition [ N ( G ) -nitro-L-arginine ( L-NNA ) ], RhoA activation [lysophosphatidic acid (LPA) ] and Rho kinase inhibition ( Y-27632 )
Takemoto et al., Circulation 2002 : Rho-kinase mediates hypoxia induced downregulation of endothelial nitric oxide synthase ... Hypoxia increased Rho-kinase expression and activity by 50 % and 74 %, decreased eNOS mRNA and protein expression by 66+/-3 % and 57+/-5 %, and inhibited eNOS activity by 48+/-9 % ... These results indicate that hypoxia induced decrease in eNOS expression is mediated by Rho-kinase and suggest that Rho-kinase inhibitors may have therapeutic benefits in patients with hypoxia induced pulmonary hypertension
Bivalacqua et al., Proc Natl Acad Sci U S A 2004 (Body Weight...) : RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis : a mechanism for diabetes associated erectile dysfunction ... RhoA/Rho-kinase may suppress endothelial nitric oxide synthase (eNOS) ... Here, we tested the hypothesis that RhoA/Rho-kinase contributes to diabetes related erectile dysfunction and down-regulation of eNOS in the streptozotocin (STZ)-diabetic rat penis
Endres et al., Stroke 2004 (Substance Withdrawal Syndrome) : Rho negatively regulates endothelial nitric oxide synthase and Rac contributes to NAD ( P ) H-oxidase activation and superoxide production
Yamanouchi et al., J Vasc Surg 2005 (Disease Models, Animal...) : In addition, we found that pravastatin inhibited Rho-kinase activity and accelerated endothelial nitric oxide synthase expression in human umbilical vein endothelial cells but did not inhibit Rho-kinase activity in vascular smooth muscle cells
Jin et al., Neurosci Lett 2006 : Hypoxia induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression ... Using the human endothelial cell line HUVEC, the present study investigated the role of RhoA and Rho-kinase in endothelial eNOS protein expression under hypoxic conditions as an in vitro model of ischemia ... Furthermore, the hypoxia induced decrease in eNOS expression was significantly enhanced by expression of the constitutively active form of Rho-kinase ... Since expression and activation of RhoA and Rho-kinase inhibit eNOS expression in endothelial cells, attempts to down-regulate RhoA and Rho-kinase by multiple drugs, such as statins or Rho-kinase inhibitors, might provide endothelial and cardiovascular benefits through upregulation of eNOS
Shin et al., J Cereb Blood Flow Metab 2007 (Brain Ischemia...) : Rho-kinase inhibition reduces cerebral infarct size in wild type, but not endothelial nitric oxide synthase deficient ( eNOS-/- ) mice ... Our results suggest that Rho-kinase negatively regulates eNOS activity in acutely ischemic brain, thereby worsening the CBF deficit ... Therefore, rapid nontranscriptional upregulation of eNOS activity by small molecule inhibitors of Rho-kinase may be a viable therapeutic approach in acute stroke
Seya et al., Eur J Pharmacol 2006 : It has been demonstrated that a small GTP binding protein, Rho , and its downstream effecter, Rho kinase ( ROCK ), negatively regulate endothelial nitric oxide synthase (eNOS) production
Abe et al., J Cardiovasc Pharmacol 2006 (Anoxia...) : However, it remains to be examined whether direct inhibition of Rho-kinase also ameliorates PH with a different etiology and whether endothelial nitric oxide synthase (eNOS) is involved in the beneficial effects of Rho-kinase inhibition
Trebicka et al., Hepatology 2007 (Liver Cirrhosis) : Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
Gien et al., Am J Physiol Lung Cell Mol Physiol 2008 (Chronic Disease...) : The effects of Rho kinase activity on angiogenesis, endothelial nitric oxide ( NO ) synthase ( eNOS ) protein expression, and NO production were determined in normal and PPHN PAECs
Suzuki et al., Arterioscler Thromb Vasc Biol 2009 : We found marked inhibition of AngII induced Rho/Rho-kinase activation and subsequent VSMC migration by eNOS gene transfer whereas G ( q ) -dependent transactivation of the epidermal growth factor receptor by AngII remains intact
Hassona et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : The activation of Rho/ROCK led to the inhibition of endothelial nitric oxide synthase expression ( 39 + or - 5.4 % ; P < 0.05 ) and phosphorylation ( 35 + or - 4.5 % ; P < 0.05 ) but also an increase in myosin light chain 20 phosphorylation ( 372 %, P < 0.05 )
Laufs et al., J Biol Chem 1998 : Because Rho GTPases undergo geranylgeranyl modification, we investigated whether Rho regulates eNOS expression ... Furthermore, inhibition of Rho by Clostridium botulinum C3 transferase ( 50 microg/ml ) or by overexpression of a dominant negative N19RhoA mutant increased eNOS expression ... These findings indicate that Rho negatively regulates eNOS expression and that HMG-CoA reductase inhibitors up-regulate eNOS expression by blocking Rho geranylgeranylation, which is necessary for its membrane associated activity