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ESR2 — NCOA2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated nuclear estrogen receptor beta network: E2/ERB (dimer)/TIF2 complex (ESR2-NCOA2) → E2/ERB (dimer) complex (ESR2) (modification, collaborate)
  Katzenellenbogen et al., Ann N Y Acad Sci 2001
  Evidence: physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor beta network: E2/ERB (dimer)/TIF2 complex (ESR2-NCOA2) → TIF2 (NCOA2) (modification, collaborate) Katzenellenbogen et al., Ann N Y Acad Sci 2001
  Evidence: physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor beta network: E2/ERB (dimer) complex (ESR2) → TIF2 (NCOA2) (modification, collaborate) Katzenellenbogen et al., Ann N Y Acad Sci 2001
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NCOA2 — ESR2 (direct interaction, fluorescent resonance energy transfer) Iannone et al., Cytometry 2001
• IRef Biogrid Interaction: NCOA2 — ESR2 (direct interaction, two hybrid) Kraichely et al., Endocrinology 2000*
• IRef Biogrid Interaction: NCOA2 — ESR2 (direct interaction, two hybrid) Monroe et al., J Endocrinol 2003*
• IRef Biogrid Interaction: NCOA2 — ESR2 (direct interaction, unspecified method) Bramlett et al., Mol Endocrinol 2001*
• IRef Biogrid Interaction: NCOA2 — ESR2 (direct interaction, fluorescent resonance energy transfer) Bai et al., Mol Endocrinol 2003*
• IRef Biogrid Interaction: NCOA2 — ESR2 (direct interaction, pull down) Kraichely et al., Endocrinology 2000*

Text-mined interactions from Literome

Labrie et al., J Steroid Biochem Mol Biol 1999 (Breast Neoplasms...) : Most importantly, the antiestrogen hydroxytamoxifen has no inhibitory effect on the SRC-1 induced ER beta activity while the pure antiestrogen EM-652 completely abolishes this effect, thus strengthening the need to use pure antiestrogens in breast cancer therapy in order to control all known aspects of ER-regulated gene expression
Hartmaier et al., Mol Endocrinol 2012 (Bone Demineralization, Pathologic...) : The coregulator steroid receptor coactivator (SRC)-1 increases transcriptional activity of the estrogen receptor ( ER ) in a number of tissues including bone
Tremblay et al., Mol Endocrinol 1997 : Moreover, the ligand independent stimulatory effect of SRC-1 on ER beta transcriptional activity is abolished by ICI 182,780, but not by OHT