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MAPK12 — ODC1
Text-mined interactions from Literome
Flamigni et al., Biochem J 1999
(Leukemia, Experimental) :
In d, l-alpha-difluoromethylornithine ( DFMO ) -resistant L1210 cells stimulated to grow from quiescence, treatment with PD98059 inhibited p44/42
MAPK phosphorylation and the
induction of
ODC activity and protein
Flamigni et al., Biochem Pharmacol 2001
(MAP Kinase Signaling System) :
The
involvement of p44/42
MAPK and p38 MAPK in the induction of
ODC was investigated by using selective inhibitors ... These results show that the p44/42 MAPK pathway, but not p38
MAPK , is
essential for
ODC induction stimulated either by agonists of G-protein coupled receptors, phorbol esters, or serum, and suggest that the inhibition of ODC induction may be an important event in the antiproliferative response to p44/42 MAPK pathway inhibitors
Kubota et al., J Natl Cancer Inst 1997
(Cell Transformation, Neoplastic...) :
Our purpose was twofold : 1 ) to determine whether ODC overexpression is directly involved in tumor cell invasion and 2 ) to determine whether
ODC overexpression
induces mitogen activated protein ( MAP ) kinase activities that are associated with cell growth and transformation
Shantz et al., Cancer Res 1998
(Cell Transformation, Neoplastic) :
Furthermore, expression of the
ODC dominant negative mutant did not
affect the phosphorylation of
mitogen activated protein kinase in nu-Raf transformed cells